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Serving the Lowcountry and Coastal Empire of Georgia and South Carolina.

William B. Knight, M.D.

William B. Knight, M.D.


Family Medicine


Board Certification:

American Board of Family Medicine

Medical School:

Doctor of Medicine, Mercer University School of Medicine, Savannah, Georgia


Family Medicine Residency, Spartanburg Regional Healthcare System, Spartanburg, South Carolina

Professional Affiliations:

American Association of Family Practice; American Medical Association; Georgia Medical Society; Wilderness Medicine Society; Medical Association of Georgia

Hospital Affiliations:

St. Joseph's/Candler; Memorial Health University Medical Center

Medical Licenses:

Georgia, South Carolina


English, Spanish
4.5 out of 5
834 Patient Ratings


At 10 years old, Dr. Knight knew that he wanted to be a doctor. He wanted to serve people and help them with the most precious thing they have – their health. His passion for medicine grew from his own medical experiences that began when he was diagnosed with a brain tumor at 4 years old. By the time he completed treatment, he was in 4th grade at Savannah Christian Preparatory School. 

He was intently focused on making good grades throughout high school and undergraduate college. Dr. Knight received undergraduate degrees with honors from Mercer University in Macon, GA in both biology and Spanish. He felt learning Spanish would help him communicate effectively with more patients. His activities included volunteering at the local hospital on a regular basis, at a local medical mission in Savannah,  and a health mission in Macon. In addition, Dr. Knight served on medical missions to rural mountainous areas in Central America. He obtained his Doctor of Medicine from Mercer University School of Medicine at the Savannah campus. Finally, Dr. Knight completed his residency in Family Medicine at Spartanburg Regional Healthcare System in Spartanburg, South Carolina.

In his practice Dr. Knight actively participates in clinical research. He understands the value that research provides as experimental treatments were part of his own medical care.  He was the first patient to ever successfully take chemotherapy drugs after becoming severely allergic to the medicine he needed. The success of this protocol was published and allows patients all over the world to continue to take life saving chemotherapy drugs that they are allergic to. It is a contribution to the medical world that gives him deep satisfaction.

He chose Family Medicine as his specialty because he loves taking care of entire families as it is special to him to be able to guide each of them on their own healthcare journey. Dr. Knight cares for all ages and believes that the foundation of a healthy lifestyle is created at an early age.

“I love taking care of all ages,” Dr. Knight explained. “It’s such a fulfilling thing to be able to address every family member’s health problems and better their lives.”

Dr. Knight feels being a doctor is a privilege that he is honored to have.  He is a native of Savannah and it brings him much satisfaction to be able to take care of people in his hometown. Through his experiences he has learned and understands the importance of compassion, sympathy, empathy, strength, and hope and strives to incorporate these traits into the care he gives his own patients.

When not at the office Dr. Knight enjoys photography and spending time outdoors.  Traveling, going to the beach, hiking especially in the mountains, cycling, camping, kayaking and attending church are some of his favorite activities. Follow him on his Instagram account @docwilladventures to see a glimpse into his life and learn some health tips along the way. You can also follow him on Facebook at William B Knight MD.

Patient Reviews

April, 2022

Jackie, Dr Knight?s nurse is really great. Thank you for being such an upbeat professional

April, 2022

Everybody was great to me I love them

April, 2022

The staff are very friendly and helpful. The doctor listens to my concerns better than my old doctor's in Illinois

April, 2022

Southcoast staff always greet the patients with kind words. I leave feeling relaxed and confident.

April, 2022

Dr. Knight is a wonderful doctor

April, 2022


March, 2022

Everyone are always friendly and helpful. You can see their smiles in their eyes. My doctor is amazing as is the rest of his staff. Nothing was a hassle. Got prescriptions refilled.

March, 2022

Dr. Knight and his staff are a pleayto work with and I will recommend them to everyone else They are very courteous and friendly.

December, 2021

Dr. Knight is an awesome doctor and is very thorough in finding the cause of illness and treatment.

December, 2021

They were very kind and helpful

November, 2021

I always feel confident in the care that I receive from Dr. Knight. He listens to my concerns and addresses them with me. He answers my questions. He doesn?t rush me out the door. Dr. Knight is an excellent physician. The medical community needs more doctors like him. The entire staff at SouthCoast Health are cordial and helpful. I will never change physicians. I respect and am great full for my physician?s expertise!

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