Serving the Lowcountry and Coastal Empire of Georgia and South Carolina.

William B. Knight, M.D.

William B. Knight, M.D.


Family Medicine, Primary Care


Board Certification:

American Board of Family Medicine

Medical School:

Doctor of Medicine, Mercer University School of Medicine, Savannah, Georgia


Family Medicine Residency, Spartanburg Regional Healthcare System, Spartanburg, South Carolina

Professional Affiliations:

American Association of Family Practice; American Medical Association; Georgia Medical Society; Wilderness Medicine Society; Medical Association of Georgia

Hospital Affiliations:

St. Joseph's/Candler; Memorial Health University Medical Center

Medical Licenses:

Georgia, South Carolina


English, Spanish
4.6 out of 5
1251 Patient Ratings


At 10 years old, Dr. Knight knew that he wanted to be a doctor. He wanted to serve people and help them with the most precious thing they have – their health. His passion for medicine grew from his own medical experiences that began when he was diagnosed with a brain tumor at 4 years old. By the time he completed treatment, he was in 4th grade at Savannah Christian Preparatory School. 

He was intently focused on making good grades throughout high school and undergraduate college. Dr. Knight received undergraduate degrees with honors from Mercer University in Macon, GA in both biology and Spanish. He felt learning Spanish would help him communicate effectively with more patients. His activities included volunteering at the local hospital on a regular basis, at a local medical mission in Savannah,  and a health mission in Macon. In addition, Dr. Knight served on medical missions to rural mountainous areas in Central America. He obtained his Doctor of Medicine from Mercer University School of Medicine at the Savannah campus. Finally, Dr. Knight completed his residency in Family Medicine at Spartanburg Regional Healthcare System in Spartanburg, South Carolina.

In his practice Dr. Knight actively participates in clinical research. He understands the value that research provides as experimental treatments were part of his own medical care.  He was the first patient to ever successfully take chemotherapy drugs after becoming severely allergic to the medicine he needed. The success of this protocol was published and allows patients all over the world to continue to take life saving chemotherapy drugs that they are allergic to. It is a contribution to the medical world that gives him deep satisfaction.

He chose Family Medicine as his specialty because he loves taking care of entire families as it is special to him to be able to guide each of them on their own healthcare journey. Dr. Knight cares for all ages and believes that the foundation of a healthy lifestyle is created at an early age.

“I love taking care of all ages,” Dr. Knight explained. “It’s such a fulfilling thing to be able to address every family member’s health problems and better their lives.”

Dr. Knight feels being a doctor is a privilege that he is honored to have.  He is a native of Savannah and it brings him much satisfaction to be able to take care of people in his hometown. Through his experiences he has learned and understands the importance of compassion, sympathy, empathy, strength, and hope and strives to incorporate these traits into the care he gives his own patients.

When not at the office Dr. Knight enjoys photography and spending time outdoors.  Traveling, going to the beach, hiking especially in the mountains, cycling, camping, kayaking and attending church are some of his favorite activities. Follow him on his Instagram account @docwilladventures to see a glimpse into his life and learn some health tips along the way. You can also follow him on Facebook at William B Knight MD.

Patient Reviews

May, 2023

In all honesty, this was my first time to the doctor for a check-up since I was a sophomore in high school. The ease of setting up an appointment, checking in, and meeting with a great doctor makes me want to recommend this to everyone.

May, 2023

Was a good experience the nurse and Dr were very polite and helpful. Answered all my questions.

May, 2023

Always have a good experience at SouthCoast. Been using them for 25 years.

April, 2023

Doctor Knight is an amazing doctor who cares about his patients and nurses are just as caring. I would definitely recommend friends and family to south coast health.

March, 2023

As always from check-in to checkout and all in between was great service. I especially enjoyed my interaction with Dr. Knight and his nursing staff they are very kind and always make my visits less stressful. I certainly appreciate their kindness.

March, 2023

Enjoyable visit. Dr. Knight and his nurse are both excellent.

March, 2023

Everyone is genuinely friendly, courteous, and kind. This is a caring and concerned staff.

March, 2023

Staff are always professional and courteous and exceptional service from Dr William Knight.

March, 2023

Dr. Knight, and his staff, are absolutely wonderful. They feel like family....based on their care of my issues and situations. They get the whole picture of possibilities contributing to my issues. Dr. Knight picks up on what is said and has an amazing ability to think outside the box. Absolutely amazing!

December, 2022

Excellent service by nurses and doctor, very satisfied

December, 2022

Doctor William Knight shows real concern for my well being. His nurses also. Thank you.

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